SCHEMBL4680285

SCHEMBL4680285

CCN(CC1CCN(S(=O)(=O)N(C)C)CC1)C(C)Cc1ccc(C(F)(F)F)cc1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.42
ALDH1A1 P00352 2/20 0.39
RAB9A P51151 1/20 0.39
LMNA P02545 2/20 0.38
TRPV4 Q9HBA0 2/20 0.36
OPRM1 P35372 1/20 0.35
OPRD1 P41143 1/20 0.35
MMP2 P08253 1/20 0.34
MMP13 P45452 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
KCNH2 Q12809 1/20 0.34
TSHR P16473 1/20 0.34
CCR5 P51681 2/20 0.34
CCR2 P41597 1/20 0.34
SLC6A9 P48067 1/20 0.34
ADAMTS7 Q9UKP4 1/20 0.34
ADAMTS5 Q9UNA0 1/20 0.34
YAP1 P46937 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4679944 0.92 CYP2D6 (0.42) CYP2D6ALDH1A1RAB9ALMNAOPRM1
SCHEMBL4682886 0.88 YAP1 (0.38) CYP2D6MMP13KCNH2TSHRCCR5
SCHEMBL4680282 0.88 CYP2D6 (0.44) CYP2D6ALDH1A1RAB9ALMNATRPV4
SCHEMBL4685575 0.85 MCHR1 (0.37) CYP2D6KCNH2TSHRCCR5YAP1
SCHEMBL4680487 0.84 CYP2D6 (0.54) CYP2D6ALDH1A1RAB9ASMN1; SMN2TSHR
Water SCHEMBL4682572 0.84 CYP2D6 (0.48) CYP2D6RAB9ALMNAOPRM1KCNH2
SCHEMBL4682468 0.84 USP2 (0.41) CYP2D6RAB9ALMNAOPRM1KCNH2
SCHEMBL4682512 0.83 CYP2D6 (0.40) CYP2D6RAB9ALMNASMN1; SMN2KCNH2
SCHEMBL4683059 0.81 CYP2D6 (0.49) CYP2D6ALDH1A1RAB9ALMNASMN1; SMN2
SCHEMBL4682363 0.81 CYP2D6 (0.41) CYP2D6RAB9ALMNASMN1; SMN2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed
EP-1058680-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-12-13 EP disclosed
WO-1999043657-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1999-09-02 WO disclosed