Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 14/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3742115 | 0.78 | NISCH (0.56) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL6992574 | 0.67 | NISCH (0.72) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL5476725 | 0.67 | NISCH (0.79) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL9375560 | 0.65 | NISCH (0.61) | NISCH | |
| SCHEMBL16863098 | 0.65 | NISCH (0.76) | NISCH | |
| SCHEMBL202587 | 0.64 | NISCH (0.48) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL9579892 | 0.64 | NISCH (0.81) | NISCH | |
| SCHEMBL28428254 | 0.63 | NISCH (0.60) | NISCHTOP2ATOP2B | |
| SCHEMBL105024 | 0.62 | NISCH (1.00) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL13167154 | 0.62 | NISCH (0.47) | NISCHLMNARECQLTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142872-B1 | AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES | SHIONOGI & CO (JP) | 2008-10-15 | — | — | EP | disclosed |
| EP-1142872-A1 | AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES | SHIONOGI & CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |