Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423454 | 0.89 | GRM5 (0.48) | GRM5MAOBLRRK2PGRCYP3A4 | |
| SCHEMBL4427166 | 0.88 | GRM5 (0.46) | GRM5MAOBSCDSCD5PGR | |
| SCHEMBL8284586 | 0.77 | GRM5 (0.54) | GRM5MAOBLRRK2PGRMAOA | |
| SCHEMBL4679544 | 0.75 | GRM5 (0.45) | GRM5HSD17B10ALDH1A1 | |
| SCHEMBL4683272 | 0.74 | XDH (0.41) | GRM5MAOBPGRMAOACYP11B2 | |
| SCHEMBL4419933 | 0.74 | PGR (0.48) | GRM5LRRK2PGRCYP2C19CYP11B2 | |
| SCHEMBL4433188 | 0.74 | GRM5 (0.43) | GRM5MAOBCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL4423954 | 0.74 | GRM5 (0.43) | GRM5MAOBPGRCYP1A2 | |
| SCHEMBL4430455 | 0.74 | GRM5 (0.49) | GRM5MAOBLRRK2PGRMAOA | |
| SCHEMBL4686098 | 0.73 | GRM5 (0.44) | GRM5MAOBLRRK2PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |