Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675767 | 0.91 | SMN1; SMN2 (0.47) | NPC1GCKMAPTGAALMNA | |
| SCHEMBL2653449 | 0.87 | GCK (0.63) | NPC1GCKMAPTGAALMNA | |
| SCHEMBL2654253 | 0.80 | GCK (0.58) | NPC1GCKMAPTGAALMNA | |
| SCHEMBL4679400 | 0.78 | NR4A2 (0.49) | NPC1MAPTGAALMNAKMT2A | |
| SCHEMBL4675406 | 0.77 | GCK (0.60) | NPC1GCKKMT2AMEN1RAB9A | |
| SCHEMBL2654506 | 0.77 | ALDH1A1 (0.48) | NPC1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL4737042 | 0.75 | GRM5 (0.44) | NPC1MAPTGAAKMT2AMEN1 | |
| SCHEMBL4677599 | 0.75 | ALDH1A1 (0.48) | NPC1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL14505772 | 0.73 | GCK (0.70) | NPC1GCKKMT2AMEN1RAB9A | |
| SCHEMBL27390389 | 0.72 | HTR4 (0.54) | NPC1MAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583532-B1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2008-07-16 | — | — | EP | disclosed |