SCHEMBL4682271

SCHEMBL4682271

COc1c(C=O)c(C)nn1C

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.55
CYP1A2 P05177 2/20 0.50
CYP2C19 P33261 2/20 0.50
CYP2C9 P11712 1/20 0.50
LMNA P02545 2/20 0.41
ALDH1A1 P00352 5/20 0.37
GAA P10253 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.35
AOC3 Q16853 1/20 0.32
NMT1 P30419 1/20 0.31
HTT P42858 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
CYP3A4 P08684 1/20 0.30
HPGD P15428 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9673792 0.80 SMN1; SMN2 (0.76) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL24885393 0.80 SMN1; SMN2 (0.37) SMN1; SMN2CYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL28757929 0.79 SMN1; SMN2 (0.51) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL25109504 0.78 SMN1; SMN2 (0.36) SMN1; SMN2CYP1A2CYP2C19CYP2C9
SCHEMBL11478780 0.76 MPO (0.40) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL11491239 0.76 SMN1; SMN2 (0.35) SMN1; SMN2CYP1A2CYP2C19CYP2C9
SCHEMBL14507097 0.74 CYP2C19 (0.38) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL9262737 0.74 SMN1; SMN2 (0.47) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL9672301 0.74 SMN1; SMN2 (0.74) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL3154381 0.74 SMN1; SMN2 (0.47) SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4655284-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES Syngenta Crop Protection AG (CH) 2025-12-03 EP disclosed
WO-2024156886-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-08-02 WO disclosed
US-10702507-B2 Endoparasite control agent THE UNIVERSITY OF TOKYO (JP) 2020-07-07 US disclosed
US-20190046511-A1 ENDOPARASITE CONTROL AGENT THE UNIVERSITY OF TOKYO (JP) 2019-02-14 US disclosed
US-20160367532-A1 ENDOPARASITE CONTROL AGENT THE UNIVERSITY OF TOKYO (JP) 2016-12-22 US disclosed
US-8735429-B2 Benzamide compounds useful as histone deacetylase inhibitors ASTRAZENECA AB (SE) 2014-05-27 US disclosed
EP-1954690-B1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS ASTRAZENECA AB (SE) 2013-05-15 EP disclosed
US-20120225907-A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS ASTRAZENECA AB (SE) 2012-09-06 US disclosed
US-8207202-B2 N-(2-aminophenyl)-4-{1-[(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}benzamide, for example; use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase ASTRAZENECA AB (SE) 2012-06-26 US disclosed
US-20080269294-A1 N-(2-aminophenyl)-4-{1-[(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}benzamide, for example; use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase ASTRAZENECA AB (SE) 2008-10-30 US disclosed
EP-1954690-A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS Astra Zeneca AB (SE) 2008-08-13 EP disclosed
WO-2007045844-A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS ASTRAZENECA AB (SE) 2007-04-26 WO disclosed
US-4226877-A ANTIPSYCHOTIC AGENTS, SCHIZOPHRENIA ABBOTT LABORATORIES (US) 1980-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160367532-A1 ENDOPARASITE CONTROL AGENT NAAA, CTRL, ENPP1 SMN1; SMN2 4395/4885CYP1A2 1264/4885CYP2C19 742/4885
US-20120225907-A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC11, HDAC5 SMN1; SMN2 3208/4885CYP1A2 1090/4885CYP2C19 795/4885
US-20080269294-A1 N-(2-aminophenyl)-4-{1-[(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}benzamide, for example; use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase HDAC1, HDAC5, HDAC2 SMN1; SMN2 1810/4885CYP1A2 1901/4885CYP2C19 2023/4885
US-20190046511-A1 ENDOPARASITE CONTROL AGENT NAAA, CTRL, ENPP1 SMN1; SMN2 4395/4885CYP1A2 1264/4885CYP2C19 742/4885
US-10702507-B2 Endoparasite control agent NAAA, CTRL, ENPP1 SMN1; SMN2 4395/4885CYP1A2 1264/4885CYP2C19 742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.