Indole-3-Acetic Acid

Indole-3-Acetic Acid

SCHEMBL468233

O=C(O)Cc1c[nH]c2ccccc12.[NaH]

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 0.73
KMT2A Q03164 8/20 0.73
MAPT P10636 7/20 0.73
KDM4E B2RXH2 5/20 0.73
ALDH1A1 P00352 4/20 0.73
SMN1; SMN2 Q16637 3/20 0.73
HPGD P15428 2/20 0.73
SLC6A2 P23975 1/20 0.69
FNTA P49354 1/20 0.69
FNTB P49356 1/20 0.69
LMNA P02545 3/20 0.64
TSHR P16473 3/20 0.61
TDP1 Q9NUW8 2/20 0.61
PMP22 Q01453 2/20 0.61
POLB P06746 2/20 0.61
RECQL P46063 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
GLA P06280 1/20 0.61
CYP2C9 P11712 1/20 0.61
NFKB1 P19838 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole-3-Acetic Acid SCHEMBL26344 0.98 MEN1 (0.75) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL7887240 0.98 MEN1 (0.75) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL29350750 0.98 MEN1 (0.75) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL1375190 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL29272696 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL29272533 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL11125791 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL31084632 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL31152574 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1
Indole-3-Acetic Acid SCHEMBL29712109 0.96 MEN1 (0.73) MEN1KMT2AMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150164860-A1 ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS TUSKEGEE UNIVERSITY (US) 2015-06-18 US claimed
US-20120108431-A1 PLANT GROWTH REGULATOR ADDITIVE TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2012-05-03 US claimed
CN-102438453-A Plant growth regulator additive TAMINCO NV 2012-05-02 CN claimed
EP-2416653-A2 PLANT GROWTH REGULATOR ADDITIVE Taminco, Naamloze Vennootschap (BE) 2012-02-15 EP claimed
WO-2010116259-A2 PLANT GROWTH REGULATOR ADDITIVE TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2010-10-14 WO claimed
WO-2009018368-A1 COMBINATION TREATMENT OF NMDA (N-METHYL-D-ASPARTATE)-ENHANCER, GLYCINE TRANSPORTER INHIBITOR, D-AMINO ACID OXIDASE INHIBITOR (DAAOI) FOR NEUROPSYCHIATRIC DISORDERS LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2009-02-05 WO claimed
CN-118077821-A Immunoregulation and growth promotion composition for improving intestinal strains of animals and application thereof 中国农业大学 2024-05-28 CN disclosed
CN-118000310-A Feed for improving weaning stress of piglets and improving intestinal health and application of feed 中国农业大学 2024-05-10 CN disclosed
CN-114681492-B Intestinal probiotics for improving metabolic diseases and application thereof 中国科学院上海营养与健康研究所 2024-04-19 CN disclosed
US-11859248-B2 Nucleic acid modification and identification method IMBA—INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) 2024-01-02 US disclosed
CN-110520540-B Nucleic acid modification and identification method IMBA-莫利库尔生物技术研究所 2023-10-03 CN disclosed
US-20230175033-A1 PRODUCTION OF JASMONATES IN FILAMENTOUS FUNGI SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-06-08 US disclosed
WO-2023101458-A1 COMPOSITION FOR PROMOTING CTCF-MEDIATED TRANSCRIPT CONDENSATION 연세대학교 산학협력단 2023-06-08 WO disclosed
WO-2009018368-A1 COMBINATION TREATMENT OF NMDA (N-METHYL-D-ASPARTATE)-ENHANCER, GLYCINE TRANSPORTER INHIBITOR, D-AMINO ACID OXIDASE INHIBITOR (DAAOI) FOR NEUROPSYCHIATRIC DISORDERS LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2009-02-05 WO disclosed
CN-1568370-A treatment of central nervous system disorders with D-amino acid oxidase and D-aspartate oxidase antagonists GENSET SA (FR) 2005-01-19 CN disclosed
EP-1412515-A2 TREATMENT OF CNS DISORDERS USING D-AMINO ACID OXIDASE AND D-ASPARTATE OXIDASE ANTAGONISTS Genset (FR) 2004-04-28 EP disclosed
US-20030185754-A1 Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists GENSET, S.A. (FR) 2003-10-02 US disclosed
US-20030166554-A1 Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists GENSET, S.A. (FR) 2003-09-04 US disclosed
WO-2003047558-A2 TREATMENT OF CNS DISORDERS USING D-AMINO ACID OXIDASE AND D-ASPARTATE OXIDASE INHIBITORS GENSET S.A. (FR) 2003-06-12 WO disclosed
WO-2002066672-A2 TREATMENT OF CNS DISORDERS USING D-AMINO ACID OXIDASE AND D-ASPARTATE OXIDASE ANTAGONISTS GENSET S.A. (FR) 2002-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030185754-A1 Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists DDO, DAO, XDH MEN1 3939/4885KMT2A 2219/4885MAPT 460/4885
US-20150164860-A1 ANTICANCER TREATMENT METHODS INVOLVING ANALOGS AND DERIVATIVES OF 3-(2-SUBSTITUTED-ETHYL) INDOLE COMPOUNDS MCL1, BAD, API5 MEN1 2451/4885KMT2A 1698/4885MAPT 4347/4885
US-20030166554-A1 Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists DDO, DAO, XDH MEN1 3939/4885KMT2A 2219/4885MAPT 460/4885
US-20120108431-A1 PLANT GROWTH REGULATOR ADDITIVE MYB, ING2, AGXT MEN1 4545/4885KMT2A 710/4885MAPT 4726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.