Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222244 | 0.87 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2MAPK1ATMKMT2A | |
| SCHEMBL4686341 | 0.87 | SMN1; SMN2 (0.60) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL3648170 | 0.85 | SMN1; SMN2 (0.53) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL3645386 | 0.83 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL5505866 | 0.83 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL4685821 | 0.83 | ATM (0.63) | POLBSMN1; SMN2MAPK1ATMKMT2A | |
| SCHEMBL5088955 | 0.82 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL4683920 | 0.82 | SMN1; SMN2 (0.58) | POLBSMN1; SMN2MAPK1ATMKMT2A | |
| SCHEMBL5088941 | 0.82 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2MAPK1ATMFAAH | |
| SCHEMBL4685710 | 0.82 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2MAPK1ATMFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989186-A1 | HYDANTOIN BASED KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| WO-2007096259-A1 | HYDANTOIN BASED KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-30 | — | — | WO | disclosed |