Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GPR88 | Q9GZN0 | 8/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088941 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL4686341 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL3645386 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL5505866 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL4685821 | 0.84 | ATM (0.63) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL5222244 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL4683920 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL4682883 | 0.82 | POLB (0.52) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL1553456 | 0.82 | FOLH1 (0.51) | SMN1; SMN2MAPK1NPC1HPGDRAB9A | |
| SCHEMBL11491274 | 0.82 | ATM (0.60) | SMN1; SMN2MAPK1NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |