Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16355237 | 0.93 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL46752 | 0.93 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL2719736 | 0.93 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL45047 | 0.92 | LMNA (0.51) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL45046 | 0.92 | LMNA (0.51) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL18059167 | 0.92 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL40061 | 0.92 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL44888 | 0.92 | CTSS (0.45) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL46886 | 0.92 | TAOK1 (0.44) | CTSSLMNAPOLBTAOK1TAOK3 | |
| SCHEMBL40200 | 0.91 | KMT2A (0.49) | CTSSLMNAPOLBTAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |