Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.63 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.44 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.44 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853637 | 1.00 | CYP3A4 (0.63) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL7309108 | 1.00 | CYP3A4 (0.63) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL9004985 | 0.97 | CYP3A4 (0.60) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL9004942 | 0.92 | CYP3A4 (0.55) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL8138746 | 0.90 | CTRB1 (0.52) | CYP3A4CTRB1CTSLCTSB | |
| SCHEMBL7302504 | 0.90 | CTRB1 (0.52) | CYP3A4CTRB1CTSLCTSB | |
| SCHEMBL7357618 | 0.90 | CYP3A4 (0.64) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL9005012 | 0.90 | CYP3A4 (0.54) | CYP3A4 | |
| SCHEMBL7569915 | 0.89 | CYP3A4 (0.63) | CYP3A4CTRB1NAMPTCTSLCTSB | |
| SCHEMBL7305488 | 0.89 | CYP3A4 (0.63) | CYP3A4CTRB1NAMPTCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997459-B1 | Intermediates for preparing retroviral protease inhibiting compounds | ABBOTT LAB (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-0486948-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |