Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.66 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | F9 | P00740 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12111212 | 0.86 | PARP15 (0.52) | PARP15RECQLGFERHSD17B10CYP1A1 | |
| SCHEMBL4686639 | 0.85 | PARP15 (0.65) | PARP15MKNK1MKNK2PARP10PARP14 | |
| SCHEMBL6140955 | 0.85 | PARP15 (0.75) | PARP15PARP10PARP14STING1 | |
| SCHEMBL4684246 | 0.79 | MELK (0.51) | F9F10HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL8034556 | 0.78 | PARP1 (0.61) | GFERLRRK2ALDH1A1 | |
| SCHEMBL15474900 | 0.78 | ALDH1A1 (0.52) | HSD17B10GPR132ALDH1A1 | |
| SCHEMBL6776817 | 0.78 | MAOB (0.53) | RECQLHSD17B10GPR132ALDH1A1 | |
| SCHEMBL6141239 | 0.78 | PARP15 (0.65) | PARP15PARP10PARP14STING1 | |
| SCHEMBL3123583 | 0.78 | L3MBTL1 (0.60) | MKNK1MKNK2RECQLCYP1A2CYP3A4 | |
| SCHEMBL7900710 | 0.78 | MAOB (0.71) | RECQLCYP3A4GPR132ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |