Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.45 |
| ▸ | LIPE | Q05469 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680352 | 0.92 | LIPE (0.47) | CNR1LIPEALDH1A1CNR2 | |
| SCHEMBL4684311 | 0.84 | CNR1 (0.45) | CNR1LIPEALDH1A1CNR2KDM4E | |
| SCHEMBL4679579 | 0.84 | CNR1 (0.52) | CNR1ALDH1A1CNR2MEN1KMT2A | |
| SCHEMBL4684134 | 0.81 | LIPE (0.44) | CNR1LIPECNR2TP53 | |
| SCHEMBL4680663 | 0.81 | LIPE (0.44) | CNR1LIPECNR2TP53 | |
| SCHEMBL4684182 | 0.77 | LIPE (0.46) | CNR1LIPECNR2 | |
| SCHEMBL4684331 | 0.76 | LIPE (0.54) | CNR1LIPECNR2KDM4EMEN1 | |
| SCHEMBL4680276 | 0.76 | CNR1 (0.52) | CNR1ALDH1A1CNR2 | |
| SCHEMBL4681228 | 0.76 | LIPE (0.43) | CNR1LIPECNR2 | |
| SCHEMBL4679631 | 0.76 | LIPE (0.47) | CNR1LIPECNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |