Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689438 | 1.00 | DRD2 (0.39) | DRD2DRD3DRD4IDO1MET | |
| SCHEMBL4687312 | 1.00 | DRD2 (0.39) | DRD2DRD3DRD4IDO1MET | |
| SCHEMBL4686705 | 0.91 | DRD2 (0.50) | DRD2DRD3DRD4IDO1MET | |
| SCHEMBL4683950 | 0.91 | DRD2 (0.50) | DRD2DRD3DRD4IDO1MET | |
| SCHEMBL4688203 | 0.74 | DRD3 (0.49) | DRD2DRD3IDO1METPIK3CG | |
| SCHEMBL4687244 | 0.74 | DRD3 (0.49) | DRD2DRD3IDO1METPIK3CG | |
| SCHEMBL4684070 | 0.73 | MET (0.45) | IDO1METNOS1AXLPIK3CG | |
| SCHEMBL21894786 | 0.69 | TRPV1 (0.40) | IDO1NOS1AXLLRRK2SLC6A4 | |
| SCHEMBL4686484 | 0.69 | SLC6A4 (0.44) | DRD2IDO1METNOS1AXL | |
| SCHEMBL27948372 | 0.67 | IDO1 (0.43) | IDO1METNOS1AXLMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753763-B1 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PFIZER LTD (GB) | 2008-08-13 | — | — | EP | claimed |