Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510525 | 1.00 | SIGMAR1 (0.47) | SIGMAR1KMT2AMEN1CSNK2BCSNK2A1 | |
| SCHEMBL4515994 | 1.00 | SIGMAR1 (0.47) | SIGMAR1KMT2AMEN1CSNK2BCSNK2A1 | |
| SCHEMBL16307073 | 0.88 | KDM4E (0.49) | KMT2AMEN1CSNK2BCSNK2A1KDM4E | |
| SCHEMBL3305638 | 0.88 | KDM4E (0.45) | KMT2AMEN1CSNK2BCSNK2A1KDM4E | |
| SCHEMBL16307001 | 0.88 | KDM4E (0.49) | KMT2AMEN1CSNK2BCSNK2A1KDM4E | |
| SCHEMBL3305644 | 0.88 | KDM4E (0.45) | KMT2AMEN1CSNK2BCSNK2A1KDM4E | |
| SCHEMBL24977629 | 0.86 | NAAA (0.45) | CSNK2BCSNK2A1NAAAALDH1A1 | |
| SCHEMBL8357541 | 0.85 | KDM4E (0.48) | SIGMAR1KMT2AMEN1CSNK2BCSNK2A1 | |
| SCHEMBL31446435 | 0.84 | CSNK2B (0.41) | KMT2AMEN1CSNK2BCSNK2A1NAAA | |
| SCHEMBL20006910 | 0.83 | PDE4B (0.44) | KMT2ACSNK2BCSNK2A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-A1 | DNA-PK INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |
| EP-2841428-A1 | DNA-PK INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2015-03-04 | — | — | EP | disclosed |
| WO-2013163190-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2013-10-31 | — | — | WO | disclosed |
| CN-101321741-A | Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols | WYETH CORP (US) | 2008-12-10 | — | — | CN | disclosed |
| EP-1957470-A1 | PROCESS FOR SELECTIVE SYNTHESIS OF ENANTIOMERS OF SUBSTITUTED 1-(2-AMINO-1-PHENYL-ETHYL)-CYCLOHEXANOLS | Wyeth (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1957470-A1 | PROCESS FOR SELECTIVE SYNTHESIS OF ENANTIOMERS OF SUBSTITUTED 1-(2-AMINO-1-PHENYL-ETHYL)-CYCLOHEXANOLS | Wyeth (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007067501-A1 | PROCESS FOR SELECTIVE SYNTHESIS OF ENANTIOMERS OF SUBSTITUTED 1-(2-AMINO-1-PHENYL-ETHYL)-CYCLOHEXANOLS | WYETH (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067501-A1 | PROCESS FOR SELECTIVE SYNTHESIS OF ENANTIOMERS OF SUBSTITUTED 1-(2-AMINO-1-PHENYL-ETHYL)-CYCLOHEXANOLS | WYETH (US) | 2007-06-14 | — | — | WO | disclosed |