Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 12/20 | 0.41 |
| ▸ | CFD | P00746 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15432809 | 0.95 | BDKRB1 (0.43) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL46854 | 0.95 | BDKRB1 (0.43) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL15432810 | 0.93 | BDKRB1 (0.41) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL46852 | 0.93 | BDKRB1 (0.41) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL16355234 | 0.89 | BDKRB1 (0.39) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL19596363 | 0.89 | BDKRB1 (0.39) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL15432811 | 0.88 | BDKRB1 (0.38) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL16804646 | 0.88 | BDKRB1 (0.38) | BDKRB1CFDTAOK1TAOK3LMNA | |
| SCHEMBL6000159 | 0.88 | CFD (0.40) | BDKRB1CFDLMNATAS1R3TAS1R1 | |
| SCHEMBL16355235 | 0.86 | BDKRB1 (0.35) | BDKRB1CFDTAOK1TAOK3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |