Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.40 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16355236 | 0.89 | SLC34A2 (0.48) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL16804647 | 0.89 | SLC34A2 (0.48) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL18471348 | 0.88 | SLC34A2 (0.49) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL46853 | 0.88 | BDKRB1 (0.41) | CFDTAS1R3TAS1R1LMNATAS1R2 | |
| SCHEMBL19596356 | 0.87 | SLC34A2 (0.46) | SLC34A2LMNACYP1A2SMN1; SMN2CYP2C19 | |
| SCHEMBL18482341 | 0.86 | SLC34A2 (0.41) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL5998996 | 0.84 | TAS1R3 (0.47) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL15432767 | 0.84 | TAS1R3 (0.47) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL6000130 | 0.84 | TAS1R3 (0.47) | CFDSLC34A2TAS1R3TAS1R1LMNA | |
| SCHEMBL40772 | 0.83 | TAS1R3 (0.50) | CFDTAS1R3TAS1R1LMNATAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |