Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685371 | 1.00 | CHRM2 (0.36) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL4685379 | 0.87 | BTK (0.39) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL16213867 | 0.82 | HRH3 (0.38) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL6120697 | 0.80 | CHRM2 (0.37) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL21159154 | 0.79 | ALDH1A1 (0.44) | BTKHRH3ALDH1A1LMNA | |
| SCHEMBL6121092 | 0.79 | ALDH1A1 (0.44) | BTKHRH3ALDH1A1LMNA | |
| SCHEMBL8153968 | 0.78 | NR1H2 (0.34) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL15653981 | 0.77 | HRH3 (0.37) | CHRM2CHRM1CHRM3BTKHRH3 | |
| SCHEMBL3195516 | 0.76 | PREP (0.40) | CHRM2CHRM1CHRM3BTKPREP | |
| SCHEMBL20405088 | 0.76 | BTK (0.46) | CHRM2CHRM1CHRM3BTKHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981847-A1 | SECONDARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007088514-A1 | SECONDARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-09 | — | — | WO | disclosed |