Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PPM1B | O75688 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121092 | 0.92 | ALDH1A1 (0.44) | HRH3BTKALDH1A1KMT2ALMNA | |
| SCHEMBL21159154 | 0.92 | ALDH1A1 (0.44) | HRH3BTKALDH1A1KMT2ALMNA | |
| SCHEMBL2303235 | 0.83 | BTK (0.38) | HRH3BTKGPR119MAPK1CHRM2 | |
| SCHEMBL12968568 | 0.83 | CHRM2 (0.40) | HRH3BTKALDH1A1GPR119KMT2A | |
| SCHEMBL6926352 | 0.83 | CHRM2 (0.40) | HRH3BTKALDH1A1GPR119KMT2A | |
| SCHEMBL4685379 | 0.82 | BTK (0.39) | HRH3BTKGPR119MAPK1CHRM2 | |
| SCHEMBL4685375 | 0.82 | CHRM2 (0.36) | HRH3BTKALDH1A1GPR119PPM1B | |
| SCHEMBL4685371 | 0.82 | CHRM2 (0.36) | HRH3BTKALDH1A1GPR119PPM1B | |
| SCHEMBL15653981 | 0.82 | HRH3 (0.37) | HRH3BTKGPR119PPM1BPTPN1 | |
| SCHEMBL30171988 | 0.81 | HRH3 (0.41) | HRH3BTKALDH1A1GPR119PPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877775-B2 | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8877775-B2 | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |