Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDE | P14735 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685444 | 0.89 | LMNA (0.43) | LMNAGAAMAPTNPSR1MAPK1 | |
| SCHEMBL444276 | 0.81 | FNTA (0.48) | LMNAGAAMAPTNPSR1MAPK1 | |
| SCHEMBL29372490 | 0.81 | FNTA (0.48) | LMNAGAAMAPTNPSR1MAPK1 | |
| SCHEMBL5371230 | 0.74 | LMNA (0.39) | LMNAGAAMAPTNPSR1MAPK1 | |
| SCHEMBL7840054 | 0.72 | FNTA (0.49) | LMNAGAAALDH1A1KDM4EPOLB | |
| SCHEMBL16239743 | 0.67 | LMNA (0.32) | LMNAGAAOPRK1 | |
| SCHEMBL2452242 | 0.67 | LMNA (0.32) | LMNAGAAOPRK1 | |
| SCHEMBL446699 | 0.67 | FNTA (0.53) | LMNAGAAMAPTNPSR1KDM4E | |
| SCHEMBL7847643 | 0.66 | FNTA (0.48) | LMNAMAPTNPSR1MAPK1ALDH1A1 | |
| SCHEMBL7839572 | 0.65 | FNTA (0.55) | LMNAGAAMAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496898-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |