Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444276 | 0.89 | FNTA (0.48) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL29372490 | 0.89 | FNTA (0.48) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL7840054 | 0.81 | FNTA (0.49) | LMNAGAAALDH1A1KDM4ECYP2C9 | |
| SCHEMBL446699 | 0.76 | FNTA (0.53) | LMNAGAANPSR1KDM4EMEN1 | |
| SCHEMBL7847643 | 0.75 | FNTA (0.48) | LMNAMAPK1NPSR1ALDH1A1CYP2C9 | |
| SCHEMBL7839572 | 0.75 | FNTA (0.55) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL4685444 | 0.75 | LMNA (0.43) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL7848346 | 0.75 | FNTA (0.49) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL4685441 | 0.74 | LMNA (0.42) | LMNAGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL16239743 | 0.74 | LMNA (0.32) | LMNAGAAOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262186-B2 | Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20050176737-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176737-A1 | Mitotic kinesin inhibitors | KIF5B, KIFC1, KIF2C | LMNA 2951/4885GAA 1295/4885MAPK1 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.