Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | WRN | Q14191 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426647 | 0.95 | PGR (0.45) | PGRCYP11B2CYP2C19GRM5MAOA | |
| SCHEMBL4423877 | 0.94 | WRN (0.45) | WRNCYP11B2TP53THRBCYP2C19 | |
| SCHEMBL13824745 | 0.85 | CYP2C19 (0.47) | WRNCYP2C19GRM5MAOAMAOB | |
| SCHEMBL4421767 | 0.85 | CYP2C19 (0.45) | PGRTP53CYP2C19GRM5MAOA | |
| SCHEMBL4429683 | 0.84 | HSD17B1 (0.50) | WRNCYP2C19GRM5MAOAMAOB | |
| SCHEMBL4425797 | 0.84 | CYP2C19 (0.42) | CYP2C19GRM5MAOAMAOBALDH1A1 | |
| SCHEMBL4426157 | 0.83 | CYP2C19 (0.44) | CYP2C19GRM5MAOAMAOBALDH1A1 | |
| SCHEMBL4422371 | 0.82 | MAP4K1 (0.43) | WRNTP53CYP2C19ALDH1A1HTT | |
| SCHEMBL4423520 | 0.82 | WRN (0.40) | WRNCYP11B2CYP2C19MAOAMAOB | |
| SCHEMBL4432498 | 0.82 | PIK3CD (0.40) | CYP2C19GRM5MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |