Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | CCKAR | P32238 | 3/20 | 0.38 |
| ▸ | CCKBR | P32239 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689937 | 0.86 | FGFR4 (0.40) | PKMALDH1A1KDM4EBLMMAPK1 | |
| SCHEMBL4690757 | 0.84 | FGFR4 (0.39) | PKMKDM4EBLMMAPK1HSD17B10 | |
| SCHEMBL4686754 | 0.83 | EGFR (0.38) | PKMKDM4EBLMMAPK1HSD17B10 | |
| Acetic Acid SCHEMBL4686845 | 0.83 | FGFR4 (0.38) | PKMKDM4EBLMMAPK1HSD17B10 | |
| SCHEMBL6212461 | 0.83 | EGFR (0.38) | MAPK1 | |
| Acetic Acid SCHEMBL4687570 | 0.82 | EGFR (0.37) | PKMKDM4EBLMMAPK1HSD17B10 | |
| SCHEMBL4686694 | 0.81 | FGFR4 (0.39) | PKMALDH1A1KDM4EBLMMAPK1 | |
| SCHEMBL4686744 | 0.80 | FGFR4 (0.45) | PKMALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL4689939 | 0.79 | FGFR4 (0.44) | PKMKMT2AMEN1KDM4ETSHR | |
| SCHEMBL4689961 | 0.79 | FGFR4 (0.42) | PKMALDH1A1KDM4EBLMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556384-B1 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2008-02-20 | — | — | EP | claimed |