Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 8/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4686845 | 0.98 | FGFR4 (0.38) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL4689937 | 0.92 | FGFR4 (0.40) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL4686791 | 0.91 | FGFR4 (0.39) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL6706766 | 0.89 | EGFR (0.38) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL4686754 | 0.89 | EGFR (0.38) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL14290437 | 0.89 | EGFR (0.38) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL6212461 | 0.89 | EGFR (0.38) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| Acetic Acid SCHEMBL4687570 | 0.88 | EGFR (0.37) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL4686694 | 0.87 | FGFR4 (0.39) | FGFR4EGFRPDGFRBFGFR1PDGFRA | |
| SCHEMBL4686744 | 0.86 | FGFR4 (0.45) | FGFR4EGFRPDGFRBFGFR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556384-B1 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2008-02-20 | — | — | EP | claimed |