Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706766 | 0.90 | EGFR (0.38) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4686754 | 0.90 | EGFR (0.38) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL14290437 | 0.90 | EGFR (0.38) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4689937 | 0.90 | FGFR4 (0.40) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| Acetic Acid SCHEMBL4687570 | 0.89 | EGFR (0.37) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4690757 | 0.89 | FGFR4 (0.39) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4686791 | 0.89 | FGFR4 (0.39) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| Acetic Acid SCHEMBL4686845 | 0.87 | FGFR4 (0.38) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4686694 | 0.85 | FGFR4 (0.39) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL4785400 | 0.84 | FGFR4 (0.45) | EGFRFGFR4PDGFRBFGFR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556384-A2 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004018472-A2 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-04 | — | — | WO | disclosed |