Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686176 | 1.00 | LMNA (0.47) | LMNAMEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL2007627 | 0.95 | LMNA (0.49) | LMNAMEN1KMT2ACYP2D6OPRM1 | |
| SCHEMBL2007624 | 0.95 | LMNA (0.49) | LMNAMEN1KMT2ACYP2D6OPRM1 | |
| SCHEMBL2009647 | 0.95 | LMNA (0.51) | LMNAMEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL2009645 | 0.95 | LMNA (0.51) | LMNAMEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL2008997 | 0.85 | LMNA (0.49) | LMNAMEN1KMT2ACYP2D6OPRM1 | |
| SCHEMBL2008995 | 0.85 | LMNA (0.49) | LMNAMEN1KMT2ACYP2D6OPRM1 | |
| SCHEMBL2012179 | 0.81 | KDM4E (0.50) | MEN1KMT2AMAPTSIGMAR1MAPK1 | |
| SCHEMBL2005831 | 0.80 | LMNA (0.42) | LMNAMEN1KMT2AMAPK1CNR1 | |
| SCHEMBL2006503 | 0.77 | GPR183 (0.57) | LMNAMEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |