Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554297 | 0.87 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL3537551 | 0.87 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL6591721 | 0.84 | P2RX1 (0.64) | ALDH1A1SMN1; SMN2KMT2AKCNMA1P2RX1 | |
| SCHEMBL9414162 | 0.83 | APP (0.63) | ALDH1A1SMN1; SMN2KMT2AMAPK1HTT | |
| SCHEMBL13753358 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL31405649 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL40329 | 0.82 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL79163 | 0.82 | DTYMK (0.62) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL27782904 | 0.82 | KDM1A (0.64) | ALDH1A1SMN1; SMN2KMT2ATSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL1138798 | 0.81 | DTYMK (0.60) | ALDH1A1SMN1; SMN2KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |