Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 11/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181626 | 0.89 | MEN1 (1.00) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL22164645 | 0.82 | HTT (0.81) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL22290778 | 0.81 | EGFR (0.80) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL31429504 | 0.81 | EGFR (0.80) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL4690315 | 0.80 | MEN1 (0.82) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL13059538 | 0.80 | HDAC3 (0.85) | MEN1KMT2AEGFRERBB2HDAC3 | |
| SCHEMBL8809879 | 0.79 | EGFR (0.82) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL7708517 | 0.79 | EGFR (0.77) | EGFRLCKHDAC3HDAC1HDAC6 | |
| SCHEMBL13192098 | 0.79 | EGFR (0.97) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL22291160 | 0.78 | MEN1 (0.78) | MEN1KMT2AHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |