Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.97 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.80 |
| ▸ | HTT | P42858 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642772 | 0.90 | EGFR (0.80) | EGFRERBB2HTTKMT2AKDM4E | |
| SCHEMBL6181626 | 0.88 | MEN1 (1.00) | EGFRHTTKMT2AKDM4EMEN1 | |
| SCHEMBL22164645 | 0.88 | HTT (0.81) | EGFRERBB2HTTKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL22290778 | 0.87 | EGFR (0.80) | EGFRERBB2HTTKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL31429504 | 0.87 | EGFR (0.80) | EGFRERBB2HTTKMT2AKDM4E | |
| SCHEMBL6179448 | 0.87 | EGFR (1.00) | EGFRHTTKMT2AKDM4EMEN1 | |
| SCHEMBL22299723 | 0.84 | HTT (0.74) | EGFRERBB2HTTKMT2AKDM4E | |
| SCHEMBL22299722 | 0.84 | HTT (0.74) | EGFRERBB2HTTKMT2AKDM4E | |
| SCHEMBL22169931 | 0.84 | HTT (0.74) | EGFRERBB2HTTKMT2AKDM4E | |
| SCHEMBL643975 | 0.83 | HDAC3 (1.00) | EGFRERBB2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | EGFR 2099/4885ERBB2 1952/4885HTT 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.