Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687945 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4687282 | 0.99 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4687279 | 0.99 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4688113 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4688110 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4691022 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4691019 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AHPGDMEN1MAPT | |
| SCHEMBL4690923 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AHPGDMEN1ALDH1A1 | |
| SCHEMBL27533555 | 0.80 | KDM4E (0.54) | KMT2AHPGDMEN1MAPTLMNA | |
| SCHEMBL4688681 | 0.76 | LMNA (0.54) | SMN1; SMN2KMT2AHPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |