Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687282 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL4691022 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4691019 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4687279 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL4688113 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4687943 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4687945 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4688110 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL4688953 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL4688958 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDKMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |