Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 12/20 | 0.56 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688462 | 1.00 | LMNA (0.57) | LMNAPOLBMAPTNPSR1PARP10 | |
| SCHEMBL14901508 | 0.86 | LMNA (0.61) | LMNAPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL31504297 | 0.85 | LMNA (0.56) | LMNAPOLBMAPTNPSR1PARP10 | |
| SCHEMBL24198673 | 0.84 | PLA2G4B (0.61) | LMNAPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL17908021 | 0.84 | PLA2G4B (0.61) | LMNAPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL17908101 | 0.84 | PLA2G4B (0.61) | LMNAPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL9448521 | 0.83 | POLB (0.63) | LMNAPOLBMAPTNPSR1PARP10 | |
| SCHEMBL6228324 | 0.83 | AR (0.61) | LMNAPOLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL15145314 | 0.83 | PRSS1 (0.59) | CYP2D6 | |
| SCHEMBL16724561 | 0.83 | MAPT (0.83) | LMNAPOLBMAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |