Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4930633 | 1.00 | HTR2C (0.46) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL7566975 | 0.80 | HTR2C (0.53) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9530706 | 0.79 | HTR2C (0.61) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL1366798 | 0.79 | HTR2C (0.61) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL19297061 | 0.78 | HTR2C (0.53) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2176384 | 0.76 | HTR2C (0.49) | HTR2CHTR6SIGMAR1KHKQDPR | |
| Hydrochloric Acid SCHEMBL29882704 | 0.75 | HTR2C (0.56) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL5317969 | 0.75 | HTR2C (0.56) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL5321408 | 0.75 | HTR6 (0.59) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2171943 | 0.75 | HTR6 (0.59) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828125-B1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET SOC CIV (FR) | 2008-04-09 | — | — | EP | disclosed |
| EP-1828125-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006058993-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANDS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2006-06-08 | — | — | WO | disclosed |