Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.57 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | MASP2 | O00187 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15689597 | 1.00 | MEN1 (0.57) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL4688695 | 1.00 | MEN1 (0.57) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6799467 | 0.90 | ALOX5 (0.61) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6799468 | 0.90 | ALOX5 (0.61) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL30199710 | 0.89 | PLCG2 (0.55) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6793560 | 0.85 | KMT2A (0.75) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6793562 | 0.85 | KMT2A (0.75) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL17176852 | 0.85 | PLCG2 (0.61) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6794623 | 0.82 | MASP2 (0.62) | MEN1KMT2ATNNI3CRHBPTNNT2 | |
| SCHEMBL6794620 | 0.82 | MASP2 (0.62) | MEN1KMT2ATNNI3CRHBPTNNT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |