Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46823 | 0.85 | SLC34A2 (0.68) | SLC34A2LMNARAB9A | |
| SCHEMBL19595926 | 0.84 | SLC34A2 (0.46) | SLC34A2KCNH2TOP2AALDH1A1NPC1 | |
| SCHEMBL15432870 | 0.83 | TAS1R3 (0.46) | SLC34A2ALDH1A1KDM4ELMNA | |
| SCHEMBL18482346 | 0.79 | SLC34A2 (0.38) | SLC34A2KCNH2NPC1RAB9A | |
| SCHEMBL45704 | 0.78 | MEN1 (0.45) | ATRCYP4F2CYP4A11F10KDM4E | |
| SCHEMBL19595990 | 0.78 | SLC34A2 (0.47) | SLC34A2ATRALDH1A1NPC1LMNA | |
| SCHEMBL15444448 | 0.77 | SLC34A2 (0.60) | SLC34A2CYP4F2CYP4A11LMNA | |
| SCHEMBL19595763 | 0.77 | SLC34A2 (0.62) | SLC34A2TOP2AALDH1A1NPC1LMNA | |
| SCHEMBL19595744 | 0.77 | SLC34A2 (0.62) | SLC34A2TOP2AALDH1A1NPC1LMNA | |
| SCHEMBL19596067 | 0.77 | SLC34A2 (0.62) | SLC34A2TOP2AALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |