Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 7/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40283 | 0.85 | ACACB (0.39) | MEN1KMT2ARAB9APARP1F10 | |
| SCHEMBL46887 | 0.78 | SLC34A2 (0.47) | RAB9AF10ATRKDM4ECYP4F2 | |
| SCHEMBL3646900 | 0.77 | MEN1 (0.51) | MEN1KMT2APARP1SIRT2PARP10 | |
| SCHEMBL15088186 | 0.74 | ADRA2C (0.44) | MEN1KMT2ARAB9AF10FOLH1 | |
| SCHEMBL9717435 | 0.74 | MEN1 (0.45) | MEN1KMT2APARP1PARP10 | |
| SCHEMBL24968900 | 0.73 | FOLH1 (0.42) | PARP1CYP4F2CYP4A11FOLH1 | |
| SCHEMBL5020909 | 0.71 | LMNA (0.49) | MEN1KMT2ARAB9AFOLH1CDK4 | |
| SCHEMBL15444430 | 0.71 | CYP4F2 (0.38) | PARP1CYP4F2CYP4A11 | |
| SCHEMBL128134 | 0.70 | PARP1 (0.57) | MEN1KMT2APARP1F10PARP10 | |
| Adipic Acid SCHEMBL28590163 | 0.70 | MEN1 (0.57) | MEN1KMT2APARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590965-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012006474-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |