Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468497 | 0.78 | DHODH (0.55) | DHODH | |
| SCHEMBL2844577 | 0.68 | DHODH (0.61) | DHODH | |
| SCHEMBL12983459 | 0.65 | PIK3CD (0.39) | DGAT1PIK3CDMAPK1CRHR1EGLN1 | |
| SCHEMBL3844536 | 0.64 | HCAR3 (0.40) | DGAT1MAPK1KDM4EALDH1A1EGLN1 | |
| SCHEMBL1505121 | 0.62 | KDM4E (0.52) | KDM4EALDH1A1CSNK2A1 | |
| SCHEMBL20251356 | 0.61 | MEN1 (0.44) | MAPK1KDM4EALDH1A1 | |
| SCHEMBL3984301 | 0.61 | KDM4C (0.42) | KDM4EALDH1A1GAAGPBAR1 | |
| SCHEMBL15966077 | 0.61 | GRM4 (0.43) | PIK3CDALDH1A1PKM | |
| SCHEMBL16994788 | 0.60 | HTT (0.51) | CRHR1GAA | |
| SCHEMBL17075550 | 0.60 | KDM4E (0.56) | DGAT1PIK3CDMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389197-A1 | COMBINATIONS COMPRISING METHOTREXATE AND DHODH INHIBITORS | Almirall S.A. (ES) | 2011-11-30 | — | — | EP | claimed |
| US-20110253957-A1 | Compliant motion distribution system | FLEXSYS, INC. | 2011-10-20 | — | — | US | claimed |
| WO-2010083975-A1 | COMBINATIONS COMPRISING METHOTREXATE AND DHODH INHIBITORS | ALMIRALL, S.A. (ES) | 2010-07-29 | — | — | WO | claimed |