Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 10/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | SELL | P14151 | 1/20 | 0.55 |
| ▸ | SELP | P16109 | 1/20 | 0.55 |
| ▸ | FUT4 | P22083 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12610191 | 0.85 | PTPN11 (0.68) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL20187628 | 0.85 | PTPN11 (0.68) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL19393187 | 0.82 | PTPN11 (0.60) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL12610000 | 0.81 | PTPN11 (0.77) | PTPN11CA12CA1CA2CA3 | |
| 7-Deshydroxypyrogallin-4-Carboxylic Acid SCHEMBL12609998 | 0.81 | PTPN11 (0.73) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL524294 | 0.78 | CA12 (0.73) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL686591 | 0.76 | CA12 (0.61) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL29914372 | 0.76 | CA12 (0.61) | PTPN11KDM4EALDH1A1TP53MAPT | |
| SCHEMBL19509567 | 0.74 | KDM4E (0.55) | PTPN11KDM4EALDH1A1TP53MAPT | |
| Gallic Acid SCHEMBL678990 | 0.73 | CA12 (1.00) | PTPN11KDM4EALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAGGIES PEARL LLC (US) | 2022-04-28 | — | — | US | disclosed |
| US-11160794-B2 | Methods for treating congenital disorders of glycosylation | MAGGIE'S PEARL, LLC (US) | 2021-11-02 | — | — | US | disclosed |
| US-20210030721-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | PERLARA PBC | 2021-02-04 | — | — | US | disclosed |
| WO-2020040831-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | PERLARA PBC (US) | 2020-02-27 | — | — | WO | disclosed |
| EP-2433625-B1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | SUNTORY HOLDINGS LTD (JP) | 2017-09-27 | — | — | EP | disclosed |
| US-9169231-B2 | Anti-obesity agent comprising compound containing benzotropolone ring | SUNTORY HOLDINGS LIMITED (JP) | 2015-10-27 | — | — | US | disclosed |
| US-9169231-B2 | Anti-obesity agent comprising compound containing benzotropolone ring | SUNTORY HOLDINGS LIMITED (JP) | 2015-10-27 | — | — | US | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150038573-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | SUNTORY HOLDINGS LIMITED (JP) | 2015-02-05 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140121388-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | SUNTORY HOLDINGS LIMITED (JP) | 2014-05-01 | — | — | US | disclosed |
| US-20140121388-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | SUNTORY HOLDINGS LIMITED (JP) | 2014-05-01 | — | — | US | disclosed |
| US-8658237-B2 | Anti-obesity agent comprising compound containing benzotropolone ring | SUNTORY HOLDINGS LIMITED (JP) | 2014-02-25 | — | — | US | disclosed |
| US-8658237-B2 | Anti-obesity agent comprising compound containing benzotropolone ring | SUNTORY HOLDINGS LIMITED (JP) | 2014-02-25 | — | — | US | disclosed |
| WO-2013074059-A2 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20120065410-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | SUNTORY HOLDINGS LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| WO-2011048011-A2 | BENZOTROPOLONE DERIVATIVES AS ANTIMICROBIAL AGENTS | BASF SE (DE) | 2011-04-28 | — | — | WO | disclosed |
| US-7288680-B2 | Benzotropolone derivatives and modulation of inflammatory response | WELLGEN, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| US-7288680-B2 | Benzotropolone derivatives and modulation of inflammatory response | WELLGEN, INC. (US) | 2007-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065410-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | PNLIP, GAA, LIPC | PTPN11 2838/4885KDM4E 1234/4885ALDH1A1 422/4885 |
| US-20150038573-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | PNLIP, GAA, LIPC | PTPN11 2838/4885KDM4E 1234/4885ALDH1A1 422/4885 |
| US-11160794-B2 | Methods for treating congenital disorders of glycosylation | MAN1B1, MAN2B1, GAA | PTPN11 2042/4885KDM4E 3915/4885ALDH1A1 1692/4885 |
| US-20210030721-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAN1B1, MAN2B1, GAA | PTPN11 2042/4885KDM4E 3915/4885ALDH1A1 1692/4885 |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | CDA, DCTD, ADA | PTPN11 4866/4885KDM4E 1984/4885ALDH1A1 2191/4885 |
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAN1B1, MAN2B1, GAA | PTPN11 2042/4885KDM4E 3915/4885ALDH1A1 1692/4885 |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | KDM1B, KDM1A, JMJD1C | PTPN11 1520/4885KDM4E 19/4885ALDH1A1 1314/4885 |
| US-20140121388-A1 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING | PNLIP, GAA, LIPC | PTPN11 2838/4885KDM4E 1234/4885ALDH1A1 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.