Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4694100 | 0.92 | GRM2 (0.36) | DHFRADORA2ADHODHMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL5389702 | 0.91 | DHFR (0.38) | DHFR | |
| SCHEMBL4691286 | 0.90 | DHFR (0.49) | DHFRSLC2A1ADORA2AMAP4K4DCPS | |
| Trifluoroacetic Acid SCHEMBL4688811 | 0.90 | DHFR (0.40) | DHFRSLC2A1ADORA3ADORA2AADORA1 | |
| Trifluoroacetic Acid SCHEMBL4692719 | 0.89 | ADORA2A (0.41) | DHFRSLC2A1ADORA2ACHUKMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL4693582 | 0.89 | F2R (0.36) | DHFRIKBKBDHODH | |
| Trifluoroacetic Acid SCHEMBL4693587 | 0.88 | F2R (0.37) | DHFRSLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5387603 | 0.88 | DHFR (0.43) | DHFRSLC2A1ADORA1 | |
| Trifluoroacetic Acid SCHEMBL4687931 | 0.87 | DHFR (0.33) | DHFRMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL4690959 | 0.86 | DHFR (0.41) | DHFRSLC2A1ADORA2AADORA1DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628979-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-20070270445-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2007-11-22 | — | — | US | disclosed |
| US-7262297-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20040235872-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | BERTHEL STEVEN JOSEPH (US) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235872-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | PTPN5, PPP5C, PTP4A2 | DHFR 289/4885SLC2A1 271/4885ADORA3 2832/4885 |
| US-20070270445-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | PTPN5, DUSP15, PPP5C | DHFR 339/4885SLC2A1 298/4885ADORA3 2940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.