Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692790 | 0.76 | CYP2D6 (0.36) | LMNASLC6A2SLC6A4TP53SMN1; SMN2 | |
| SCHEMBL28640840 | 0.74 | MEN1 (0.38) | SLC6A2SLC6A4TP53ALDH1A1MAOB | |
| SCHEMBL6681144 | 0.74 | CYP2D6 (0.35) | LMNASLC6A2SLC6A4CYP2D6CYP3A4 | |
| SCHEMBL2059899 | 0.72 | MAOB (0.38) | SLC6A2SLC6A4TP53ALDH1A1MAOB | |
| SCHEMBL149530 | 0.71 | MAOB (0.36) | LMNASLC6A2SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL2566542 | 0.69 | TSHR (0.38) | LMNATP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL10964311 | 0.67 | SLC6A2 (0.33) | LMNASLC6A2SLC6A4TP53ALDH1A1 | |
| SCHEMBL11704959 | 0.67 | MAPT (0.40) | TP53ALDH1A1MAPTNPSR1CRHBP | |
| SCHEMBL2566392 | 0.67 | AOC3 (0.37) | LMNATP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL28570141 | 0.66 | SLC6A2 (0.46) | LMNASLC6A2SLC6A4TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1419160-B1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-7078535-B2 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| US-20040236117-A1 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2004-11-25 | — | — | US | disclosed |
| EP-1419160-A1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018583-A1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236117-A1 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | KMO, HPD, PDK4 | LMNA 4513/4885SLC6A2 1957/4885SLC6A4 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.