Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.60 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685284 | 0.93 | PARP15 (0.61) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL4684034 | 0.87 | PARP15 (0.59) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL4685392 | 0.85 | PARP15 (0.60) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL4687671 | 0.85 | PARP15 (0.60) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL4684289 | 0.84 | PARP15 (0.56) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL12970666 | 0.82 | PARP15 (0.54) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL4685251 | 0.82 | PARP10 (0.63) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL12970678 | 0.82 | PARP15 (0.56) | PARP15PARP10PARP14THRATHRB | |
| SCHEMBL22498547 | 0.81 | CA2 (0.55) | ALDH1A1HPGDLMNAHTTAPP | |
| SCHEMBL12970679 | 0.81 | PARP15 (0.55) | PARP15PARP10PARP14THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |