Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.60 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684034 | 0.93 | PARP15 (0.59) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL4684289 | 0.90 | PARP15 (0.56) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL4685284 | 0.90 | PARP15 (0.61) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL4687671 | 0.88 | PARP15 (0.60) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL11775703 | 0.86 | ALDH1A1 (0.53) | PARP15PARP10ALDH1A1HPGDTHRA | |
| SCHEMBL4689682 | 0.85 | PARP15 (0.60) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL4685251 | 0.84 | PARP10 (0.63) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL12970678 | 0.84 | PARP15 (0.56) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL12970679 | 0.83 | PARP15 (0.55) | PARP15PARP10PARP14ALDH1A1HPGD | |
| SCHEMBL4374860 | 0.82 | CA2 (0.57) | ALDH1A1HPGDHIF1ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507243-B1 | SPIROINDOLINONE PYRROLIDINES | HOFFMANN LA ROCHE (CH) | 2015-06-10 | — | — | EP | claimed |
| EP-2507243-A1 | SPIROINDOLINONE PYRROLIDINES | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | claimed |
| US-8217044-B2 | Spiroindolinone pyrrolidines | HOFFMANN-LA ROCHE INC. (US) | 2012-07-10 | — | — | US | claimed |
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |
| EP-2507243-B1 | SPIROINDOLINONE PYRROLIDINES | HOFFMANN LA ROCHE (CH) | 2015-06-10 | — | — | EP | disclosed |
| EP-2507243-A1 | SPIROINDOLINONE PYRROLIDINES | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | disclosed |