Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 12/20 | 0.70 |
| ▸ | ITGB2 | P05107 | 11/20 | 0.70 |
| ▸ | ICAM1 | P05362 | 11/20 | 0.70 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690170 | 0.90 | ITGAL (0.57) | ITGALITGB2ICAM1 | |
| SCHEMBL4686803 | 0.90 | ITGAL (0.57) | ITGALITGB2ICAM1ELANE | |
| SCHEMBL4689932 | 0.83 | ITGAL (1.00) | ITGALITGB2ICAM1ELANEPGR | |
| SCHEMBL4686807 | 0.74 | ITGAL (0.82) | ITGALITGB2ICAM1ELANE | |
| SCHEMBL13879533 | 0.69 | ITGAL (0.76) | ITGALITGB2ICAM1ELANETSHR | |
| SCHEMBL4687618 | 0.68 | ITGB2 (0.41) | ITGALITGB2ICAM1ALDH1A1CYP1A2 | |
| SCHEMBL17716270 | 0.66 | ELANE (0.87) | ITGALITGB2ICAM1ELANEPGR | |
| SCHEMBL13817154 | 0.64 | ITGB2 (0.79) | ITGALITGB2ICAM1 | |
| SCHEMBL17716269 | 0.63 | ELANE (0.73) | ITGALITGB2ICAM1ELANEPGR | |
| SCHEMBL19184961 | 0.63 | ELANE (0.73) | ITGALITGB2ICAM1ELANEPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | claimed |
| EP-1399155-A4 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1399155-A2 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-03-24 | — | — | EP | claimed |
| US-6414153-B1 | TREATMENT OF INFLAMMATORY OR IMMUNE CELL-MEDIATED DISEASE OR CONDITION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-07-02 | — | — | US | claimed |
| WO-2001006984-A2 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | claimed |
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-6414153-B1 | TREATMENT OF INFLAMMATORY OR IMMUNE CELL-MEDIATED DISEASE OR CONDITION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-07-02 | — | — | US | disclosed |