Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 7/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690740 | 0.93 | CCR5 (0.42) | CCR5KCNH2 | |
| SCHEMBL4690445 | 0.93 | EPHX2 (0.38) | CCR5KCNH2EPHX2 | |
| SCHEMBL4690611 | 0.93 | CCR5 (0.37) | CCR5KCNH2UBE2MDCUN1D1EPHX2 | |
| SCHEMBL4694148 | 0.92 | MAPT (0.36) | CCR5KCNH2UBE2MDCUN1D1EPHX2 | |
| SCHEMBL4694074 | 0.92 | MCHR1 (0.36) | CCR5KCNH2EPHX2 | |
| SCHEMBL4694952 | 0.91 | CCR5 (0.37) | CCR5KCNH2UBE2MDCUN1D1 | |
| SCHEMBL4695361 | 0.91 | CCR5 (0.37) | CCR5KCNH2EPHX2 | |
| SCHEMBL4691638 | 0.91 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694017 | 0.90 | CCR5 (0.43) | CCR5KCNH2EPHX2 | |
| SCHEMBL4690521 | 0.90 | CCR5 (0.34) | CCR5KCNH2UBE2MDCUN1D1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |