Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 14/20 | 0.38 |
| ▸ | CCL5 | P13501 | 8/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5661812 | 0.90 | CCL5 (0.40) | CCR5CCL5 | |
| SCHEMBL4699414 | 0.89 | CCR5 (0.40) | CCR5CCL5 | |
| SCHEMBL4696220 | 0.88 | CCL5 (0.41) | CCR5CCL5 | |
| SCHEMBL4691440 | 0.87 | CCR5 (0.41) | CCR5CCL5 | |
| SCHEMBL4696117 | 0.85 | CCR5 (0.41) | CCR5CCL5 | |
| SCHEMBL4695015 | 0.84 | CCR5 (0.40) | CCR5CCL5 | |
| SCHEMBL4694907 | 0.84 | CCL5 (0.43) | CCR5CCL5 | |
| SCHEMBL4694360 | 0.83 | CCL5 (0.39) | CCR5CCL5 | |
| SCHEMBL4698176 | 0.83 | CCR5 (0.40) | CCR5CCL5 | |
| SCHEMBL5659665 | 0.83 | CCL5 (0.38) | CCR5CCL5AURKACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |