Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.56 |
| ▸ | CHUK | O15111 | 3/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688357 | 0.83 | IKBKB (0.53) | IKBKBCHUKCSF1RBTK | |
| Hydrochloric Acid SCHEMBL1686965 | 0.82 | HTR2C (0.43) | IKBKBCHUKCSF1RBTKHTR2C | |
| SCHEMBL10075358 | 0.82 | HTR2C (0.43) | IKBKBCHUKCSF1RBTKHTR2C | |
| SCHEMBL4686046 | 0.81 | IKBKB (0.62) | IKBKBCHUKCSF1RBTK | |
| SCHEMBL5306819 | 0.81 | IKBKB (0.53) | IKBKBCHUKHTR2CSIGMAR1 | |
| SCHEMBL3792407 | 0.77 | HTR1A (0.56) | IKBKBCHUKDRD2 | |
| SCHEMBL4688714 | 0.77 | TDO2 (0.56) | IKBKBCHUKBTK | |
| SCHEMBL14030843 | 0.76 | IKBKB (0.57) | IKBKBCHUKCSF1RBTK | |
| SCHEMBL7392593 | 0.74 | JAK2 (0.69) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL4686501 | 0.74 | IKBKB (0.54) | IKBKBCHUKCSF1RBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703905-B1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-11-12 | — | — | EP | disclosed |