Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 19/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690542 | 0.91 | HCRTR1 (0.39) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL4695197 | 0.90 | HCRTR1 (0.38) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL5662693 | 0.88 | HCRTR1 (0.43) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL4693139 | 0.88 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL4691904 | 0.88 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL4689931 | 0.87 | HCRTR1 (0.39) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL4693290 | 0.87 | PDE10A (0.40) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL4692886 | 0.86 | ALDH1A1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL4694165 | 0.86 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL4695647 | 0.86 | HCRTR1 (0.48) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |