SCHEMBL4692886

SCHEMBL4692886

Cc1ccc(C(CC(N)=O)N2CC3CN(C(=O)c4ccccc4C)CC3C2)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
GBA1 P04062 1/20 0.42
TNF P01375 1/20 0.41
MAPT P10636 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HCRTR1 O43613 6/20 0.40
HCRTR2 O43614 6/20 0.40
KMT2A Q03164 2/20 0.40
HTT P42858 2/20 0.39
KCNK3 O14649 1/20 0.39
KCNK9 Q9NPC2 1/20 0.39
MGLL Q99685 1/20 0.39
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
HTR2B P41595 1/20 0.38
MAPK14 Q16539 1/20 0.38
MEN1 O00255 1/20 0.38
CCR5 P51681 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4691868 0.92 HCRTR1 (0.47) ALDH1A1GBA1TNFMAPTHCRTR1
SCHEMBL4693484 0.92 HCRTR1 (0.48) ALDH1A1GBA1TNFHCRTR1HCRTR2
SCHEMBL4694224 0.92 TNF (0.39) ALDH1A1GBA1TNFMAPTNPSR1
SCHEMBL4691904 0.92 HCRTR1 (0.46) ALDH1A1TNFMAPTHCRTR1HCRTR2
SCHEMBL4694354 0.90 P2RX7 (0.44) TNFHCRTR1HCRTR2
SCHEMBL4695935 0.90 HCRTR2 (0.47) ALDH1A1TNFHCRTR1HCRTR2MGLL
SCHEMBL4690634 0.90 TNF (0.38) ALDH1A1GBA1TNFMAPTHCRTR1
SCHEMBL4691302 0.90 HCRTR1 (0.42) GBA1TNFMAPTHCRTR1HCRTR2
SCHEMBL4691405 0.90 HCRTR1 (0.48) ALDH1A1TNFHCRTR1HCRTR2HTT
SCHEMBL4694616 0.90 TNF (0.38) ALDH1A1GBA1TNFHCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP disclosed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO disclosed