Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 13/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690623 | 0.90 | MAPT (0.42) | MAPTLMNAMALT1NR1H4 | |
| SCHEMBL4691500 | 0.89 | NR1H4 (0.54) | ALDH1A1MAPTLMNAMALT1NR1H4 | |
| SCHEMBL4693420 | 0.87 | MAPT (0.45) | ALDH1A1MAPTLMNANR1H4TSHR | |
| SCHEMBL4694220 | 0.86 | NR1H4 (0.46) | MAPTLMNAMALT1NR1H4GAA | |
| SCHEMBL4695747 | 0.86 | NR1H4 (0.47) | MAPTLMNANR1H4KMT2A | |
| SCHEMBL4692823 | 0.86 | NR1H4 (0.47) | MAPTLMNAL3MBTL1NR1H4GAA | |
| SCHEMBL4691400 | 0.83 | KMT2A (0.50) | ALDH1A1HTTMAPTLMNATSHR | |
| SCHEMBL4693690 | 0.81 | HCRTR1 (0.51) | ALDH1A1HTTMAPTLMNAGAA | |
| SCHEMBL4693950 | 0.81 | HCRTR1 (0.49) | ALDH1A1HTTMAPTKMT2A | |
| SCHEMBL4691680 | 0.80 | POLB (0.52) | MAPTNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |