Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691661 | 0.93 | MAPT (0.45) | POLBTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4691500 | 0.90 | NR1H4 (0.54) | POLBTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4691686 | 0.87 | MAPT (0.48) | POLBTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4690880 | 0.87 | TP53 (0.50) | POLBTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4693150 | 0.86 | TP53 (0.53) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL4692884 | 0.84 | LMNA (0.48) | POLBTP53SMN1; SMN2MAPTHPGD | |
| SCHEMBL4695747 | 0.83 | NR1H4 (0.47) | POLBTP53SMN1; SMN2MAPTHPGD | |
| SCHEMBL4692823 | 0.83 | NR1H4 (0.47) | POLBTP53SMN1; SMN2MAPTNR1H4 | |
| SCHEMBL4694220 | 0.83 | NR1H4 (0.46) | POLBTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4694219 | 0.82 | LMNA (0.46) | POLBTP53SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |