Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | LAP3 | P28838 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL269403 | 0.82 | PTPN1 (0.49) | ALDH1A1RAB9ASMN1; SMN2PTPN1MEN1 | |
| SCHEMBL590493 | 0.82 | PTPN1 (0.49) | ALDH1A1RAB9ASMN1; SMN2PTPN1MEN1 | |
| SCHEMBL4687989 | 0.78 | SRC (0.54) | CES1KCNN4ALDH1A1KDM4ELMNA | |
| SCHEMBL6120239 | 0.74 | L3MBTL1 (0.34) | KCNN4L3MBTL1 | |
| SCHEMBL11730655 | 0.73 | CES1 (0.52) | CES1KCNN4ALDH1A1KDM4ELMNA | |
| SCHEMBL27815145 | 0.73 | ALDH1A1 (0.45) | LAP3ALDH1A1RAB9ASMN1; SMN2PTPN1 | |
| SCHEMBL5554985 | 0.70 | PTPN1 (0.46) | KCNN4ALDH1A1RAB9ASMN1; SMN2PTPN1 | |
| SCHEMBL16295744 | 0.69 | SMN1; SMN2 (0.50) | KCNN4ALDH1A1SMN1; SMN2PTPN1CTRB1 | |
| SCHEMBL12902954 | 0.69 | CES1 (0.59) | CES1ALDH1A1SMN1; SMN2CES2AKR1B1 | |
| SCHEMBL1874420 | 0.69 | L3MBTL1 (0.31) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |